Great place for a beer is the Gingerman Pub on E36 Street between 5th and Madison. 80 beers on tap, reasonably priced with good bar food. There's also two other decent bars on the block as well.
Italian wine bar/food, UVA Wine Bar on E77/2nd Avenue, fantastic wine list and great/reasonably priced Italian food. Lots of local bars within walking distance to this place afterwards.
Lower Manhattan at Laffayette/Broadway, Puck Fair is a nice bar, 50 beers on tap. Lots to do in the area bar wise.
http://www.puckfairbar.com/